Bio-Inspired, Engineered Microtopographies Reduce Platelet Adhesion and Activation on Blood-Contacting Materials (2014)

Platelet adhesion and activation are key events in thrombus or clot formation on blood-contacting biomaterials. Thus understanding the complex interactions between biomaterial surface properties and platelets is important for developing vascular access devices that limit thromboembolic events. Medical-grade poly(urethanes) are frequently used in blood-contacting medical devices due to their desirable mechanical properties and high level of hemocompatibility. Moreover, it has been shown that sub-platelet-sized micropatterns reduce platelet adhesion. Based on this evidence, we hypothesized that bio-inspired, antifouling Sharklet™ (SK) microtopographies replicated in biomedical thermoplastic poly(urethane) (TPU) reduce both platelet adhesion and activation compared to smooth (SM) controls.

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Micro-patterned polyurethane surfaces for reducing bacterial attachment associated with catheter-associated blood stream infections (2013)

Background: Central venous catheters (CVCs) are responsible for approximately 90% of all catheter-related bloodstream infections (CRBSIs). These CRBSIs, commonly caused by Staphylococcus aureus and Staphylococcus epidermidis, are associated with 28,000 deaths per year in the U.S. as well as prolonged hospital stays and increased healthcare costs. A common strategy used to prevent CRBSIs has been to impregnate CVCs with antimicrobial agents, which can be limited by the short duration of efficacy and the potential for contributing to antimicrobial resistance. A novel micro-topography may provide an alternative strategy as it has been shown to reduce bacterial attachment and biofilm formation without the use of antimicrobial agents. This micro-pattern also inhibits bacterial migration, offering the possibility of reducing bacterial access into the bloodstream via the CVC. The objective of this study was to determine the performance of the Sharklet micro-pattern in reducing S. aureus attachment to samples made in the same material as CVCs after whole blood pre-conditioning.